GDF-15治療對肝癌化療敏感性影響的分析
GDF-15治療對肝癌化療敏感性影響的分析
謝瓊 易宏鋒*
【摘要】目的 探討GDF-15(生長分化因子-15）治療對于肝癌化療敏感性的影響。方法 通過采用免疫組織化學方法SP分別檢測行GDF-15治療與未行GDF-15治療的肝癌組織中絲氨酸/蘇氨酸蛋白激酶受體(RSK)及多藥耐藥相關蛋白（MRPI）的表達情況，從而探討GDF-15對于肝癌化療敏感性的影響。結果 在20例行GDF-15治療組，其絲氨酸/蘇氨酸蛋白激酶受體(RSK)表達強度為：0.4358±0.01246，15例未行GDF-15治療組，其絲氨酸/蘇氨酸蛋白激酶受體(RSK)表達強度為：0.3012±0.01278，前者表達強度明顯高于后者（P＜0.05），因此GDF-15治療組，其療效好于非GDF-15治療組；在20例行GDF-15治療組，其多藥耐藥相關蛋白（MRPI）表達強度為：0.3574±0.02159，15例未行GDF-15治療組，其多藥耐藥相關蛋白（MRPI）表達強度為：0.3101±0.01108，前者表達強度明顯高于后者（P＜0.05），因此GDF-15治療組，其可增加肝癌對藥物的耐藥性。結論 在行肝癌化療時，家用GDF-15的治療可增強機體抗腫瘤免疫，但是另一外面可以增加肝癌對化療藥物的耐藥性，減低其敏感性，因此，對于肝癌的化療，加用GDF-15的治療可降低其效果。
【關鍵詞】 肝癌；GDF-15；絲氨酸/蘇氨酸蛋白激酶受體；多藥耐藥相關蛋白
Analysis of GDF—15 treatment for the sensitivity of liver cancer chemotherapy, Xie Qiong，Yi Hongfeng， Tianmen NO.2 People’s Hospital, Tianmen, Hubei 431700, China
【Abstract】 Objective To investigate the effecacy of GDF—15 treatment for liver cancer chemosensitivity. Methods Immunohistochemical SP was used to detect expressions of Serine/threonine protein kinase receptor (RSK) and multi-resistant protein (MRPI) in liver cancer of two groups, one was using GDF-15 treatment and the other was not, explored the effect of GDF 15-for chemosensitivity of liver cancer. Results In 20 cases with GDF-15 treatment, its serine/threonine protein kinase receptor (RSK) expression intensity was 0.4358±0.01246,while in 15 cases without GDF-15, the serine/threonine protein kinase receptor (RSK) expression intensity was 0.3012±0.01278. The former expression intensity was significantly higher than the other(P<0.05), and therefore the efficacy of group with GDF-15 was better than the group without GDF-15.In 20 cases with GDF—15, the multidrug resistance-associated protein (MRPI) expression intensity was 0.3574±0.02159,while in 15 cases without GDF—15, the multidrug resistance—associated protein (MRPI) expression intensity was 0.3101±0.01108. The former expression level was significantly higher than the other (P <0.05). Therefore the treatment group GDF-15 had higher liver cancer drug resistance. Conclusion HCC line chemotherapy, home GDF—15 treatment can enhance the body's anti—tumor immunity, but on the other side it can increase liver resistance to chemotherapeutic drugs, and reduce their sensitivity. Therefore, for liver cancer chemotherapy, using GDF—15 treatment can reduce its effectiveness.
【Key words】 Liver cancer; GDF—15; Serine/threonine protein kinase receptor; Multidrug resistance—associated protein