細(xì)胞融合在腫瘤轉(zhuǎn)移中作用的研究進(jìn)展
【摘要】細(xì)胞融合，是生物體在發(fā)展和達(dá)到動(dòng)態(tài)平衡過(guò)程中產(chǎn)生的。而腫瘤的發(fā)展是一個(gè)多步驟的復(fù)雜過(guò)程，從腫瘤的發(fā)生及生長(zhǎng)，到腫瘤發(fā)生轉(zhuǎn)移，這些過(guò)程都與細(xì)胞融合關(guān)系密切。腫瘤的轉(zhuǎn)移過(guò)程也非常復(fù)雜，原發(fā)腫瘤的生長(zhǎng)導(dǎo)致腫瘤血管生成，從而提供給腫瘤細(xì)胞侵入循環(huán)的途徑，腫瘤細(xì)胞在血液循環(huán)中繼續(xù)生存，接著滲出血管到周?chē)M織，然后轉(zhuǎn)移到新的器官，在靶器官中生存、定居、增殖，從而實(shí)現(xiàn)腫瘤的轉(zhuǎn)移。本文主要從腫瘤轉(zhuǎn)移的過(guò)程入手，初步探究細(xì)胞融合在這個(gè)過(guò)程中所發(fā)揮的作用，從而為腫瘤治療的研究提供新的目標(biāo)。
【關(guān)鍵詞】細(xì)胞融合；腫瘤轉(zhuǎn)移；血管生成；侵入；滲出
The research development of tumor metastasis in cell fusion,TAO Yue-qin,changzhou stomatological hospital,changzhou,213000,china
【Abstract】Cell fusion is produced by the organisms in the process of development and a dynamic equilibrium.Tumor development is the complexity of a multi-step process,from the occurrence and growth of the tumor,to the tumor metastasis,these processes are closely related with cell fusion.Tumor metastasis process is very complex,Primary tumor growth leading to tumor angiogenesis,thus providing a way for tumor cells enter into the circulation, tumor cells continue to survive in the blood circulation,followed by extravasation into the surrounding tissue, and then transferred to the new organ to survive in the new organ and settle proliferation,in order to achieve the transfer of the tumor.In this paper,we starting from the process of tumor metastasis,initially to explore the role of cell fusion in this process,and thus provide new targets for cancer therapy research.
【Key words】cell fusion;tumor metastasis;angiogenesis;intravasation；extravasation